What question did this study set out to answer?

The study aims to compare the efficacy and safety of tenecteplase and alteplase in patients with mild acute ischaemic stroke.

Abstract Number: Esoc2026a202 Intravenous Tenecteplase Versus Alteplase in Mild Acute Ischaemic Stroke: A Systematic Review and Meta-Analysis of Randomised Trials

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Randomized trial evaluates tenecteplase efficacy versus alteplase in mild stroke, suggesting improved outcomes.

The study aims to compare the efficacy and safety of tenecteplase and alteplase in patients with mild acute ischaemic stroke.
Systematic search of databases for randomized controlled trials comparing tenecteplase and alteplase.
Inclusion criteria: patients with baseline NIHSS ≤5.
Pooled data using random-effects model, reporting odds ratios.
Tenecteplase increased likelihood of achieving functional independence (mRS 0–1) with OR 1.28 (95% CI 1.10–1.50; p = 0.002).
Early neurological improvement favored tenecteplase with OR 1.34 (95% CI 1.08–1.68; p = 0.008).
No significant differences in symptomatic intracranial haemorrhage (OR 0.92; p = 0.76) or mortality (OR 0.89; p = 0.38).

Ibrahim Serag (2026) studied this question.

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