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May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a2308 GLP-1 or Dual Gip/GLP-1 Receptor Agonist in Acute Ischaemic Stroke: A Systematic Review and Meta-Analysis of Pre-Clinical Studies

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Authors

SESara EltirafiHKHarry KeevilVAViswesh Anand

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Overview

Systematic review investigates neuroprotective effects of GLP-1 and GIP receptors in ischaemic stroke, suggesting potential benefits.

Key Points

  • This review aims to assess the neuroprotective effects of GLP-1 receptor agonists and dual GLP-1/GIP receptor agonists in acute ischaemic stroke.
  • Identified studies through EMBASE, Medline, Web of Science, and Scopus
  • Extracted data on infarct volume, functional outcomes, mechanisms, and study quality
  • Conducted meta-analyses using random effects models, reporting standardized mean difference (SMD) and weighted mean difference (WMD)
  • Infarct volume improved post-stroke in diabetic (SMD -2.61; 95% CI -3.35, -1.87; P < 0.00001) and non-diabetic rodents (SMD -1.90; 95% CI -2.33, -1.46; P < 0.00001)
  • GLP-1RAs showed improvement in functional outcomes at Day 1 with Rotarod SMD 1.78; p = 0.09 and mNSS WMD -1.38; p = 0.17
  • At 14 days, significant improvements were seen with Rotarod SMD 0.79 (P = 0.004) and mNSS WMD -2.84 (P = 0.02)

Cite This Study

Eltirafi et al. (2026) studied this question.

synapsesocial.com/papers/69fd7eb0bfa21ec5bbf06f14https://doi.org/10.1093/esj/aakag023.1061
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1GLP-1 Receptor Agonists in Acute Ischemic Stroke and Secondary Stroke Prevention: A Narrative Review of Preclinical and Clinical Evidence2026 · 2 citations
  2. 2Glucagon-like peptide-1 receptor agonists and stroke: A systematic review and meta-analysis of cardiovascular outcome trials2024 · 33 citations
  3. 3Diabetes Mellitus and Stroke: Pathophysiological Connections and Therapeutic Potential of GLP-1 and GLP-1/GIP Receptor Agonists2026
  4. 4Efficacy of glucagon-like peptide-1 receptor agonists for prevention of stroke among patients with and without diabetes: A meta-analysis with the SELECT and FLOW trails2025 · 6 citations
  5. 5Abstract 446: Impact of GLP‐1 Receptor Agonists After Mild Stroke in Obese Patients: A Multicenter Propensity Score‐Matched Analysis2025