Actin-Dependent Regulation of RSV F-Mediated Cell-cell Fusion Revealed by Visualizing Its Spatiotemporal Dynamics

Yu Qiu; Xin Ji; Jinrui Zhang; Jing Gao; Shi YAN; Yangang Pan; Guanghua Che; Haijiao Xu; Hongda Wang

doi:10.1039/d6nh00043f

January 1, 2026Nanoscale Horizons

Actin-Dependent Regulation of RSV F-Mediated Cell-cell Fusion Revealed by Visualizing Its Spatiotemporal Dynamics

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Key Points

This research investigates how the RSV fusion protein facilitates cell-cell fusion by examining spatiotemporal dynamics in the plasma membrane.
Utilized live-cell imaging and super-resolution microscopy to visualize dynamics of the RSV fusion protein.
Focused on the actin-dependent regulatory mechanisms involved in cell-cell fusion during RSV infection.
Demonstrated that actin dynamics play a crucial role in the fusion process induced by RSV.
Identified distinct spatiotemporal patterns of the fusion protein during cell-cell fusion events.

Implication

Demonstrates cell-cell fusion dynamics in RSV-infected cells, highlighting actin's role.

Abstract

Respiratory syncytial virus (RSV) induces pathogenic syncytia via its fusion (F) protein, yet how it orchestrates fusion within the crowded plasma membrane remains unclear. By integrating live-cell and super-resolution microscopy,...

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Cite This Study

Qiu et al. (2026) studied this question.

synapsesocial.com/papers/69fd7ec6bfa21ec5bbf07100 https://doi.org/10.1039/d6nh00043f

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Actin-Dependent Regulation of RSV F-Mediated Cell-cell Fusion Revealed by Visualizing Its Spatiotemporal Dynamics

Key Points

Implication

Abstract

Discussion

Cite This Study

Actin-Dependent Regulation of RSV F-Mediated Cell-cell Fusion Revealed by Visualizing Its Spatiotemporal Dynamics

Key Points

Implication

Abstract

Discussion

Cite This Study

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