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May 8, 2026World Journal of DentistryOpen Access

Comparative Evaluation of Fluoride Varnishes on Enamel Microhardness: An In Vitro Study

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Authors

HVHP VivekHKHarish KumarNPNarendra V Penumatsa

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Overview

Randomized trial compares enamel microhardness after fluoride varnish application, suggesting MI varnish is most effective.

Key Points

  • This study aims to compare the effectiveness of different fluoride varnishes on enamel microhardness.
  • Randomly assigned 60 sound premolar samples divided into three groups of 20 samples each.
  • Each group received a different fluoride varnish: Clinpro White, MI varnish, or Fluorprotector.
  • Samples underwent pH cycling to simulate oral conditions before microhardness testing using Vickers Hardness Number.
  • MI varnish group demonstrated the highest mean enamel microhardness of 296.78 (SD 9.50).
  • Clinpro White group exhibited a mean hardness of 272.16 (SD 11.08), while Fluorprotector group had 288.26 (SD 12.64), with p = 0.0002 indicating significant differences.

Cite This Study

Vivek et al. (2026) studied this question.

synapsesocial.com/papers/69fd7ef7bfa21ec5bbf07491https://doi.org/10.5005/jp-journals-10015-2818
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Evaluation of the Effect on Enamel Solubility and Remineralizing Potential Following Surface Treatment with Fluoride-alone Varnish and Two Fluoride Varnishes Containing Calcium and Phosphate Additives: An In Vitro Study2025 · 1 citations
  2. 2Pathophysiology of Demineralization, Part II: Enamel White Spots, Cavitated Caries, and Bone Infection2022 · 59 citations
  3. 3The Effect of the Addition of Tricalcium Phosphate to 5% Sodium Fluoride Varnishes on the Microhardness of Enamel of Primary Teeth2013 · 48 citations
  4. 4Effect of different concentrations of fluoride varnish on enamel surface microhardness: An in vitro randomized controlled study2016 · 11 citations
  5. 5Ion release from calcium and fluoride containing dental varnishes2014 · 117 citations