Key result
Estimated PWV moderately correlates with directly measured PWV in acute ischemic stroke.
Why the study?
Estimated PWV offers a simple alternative to direct PWV measurement, but its correlation with directly measured PWV in acute ischemic stroke patients needed evaluation.
Does estimated pulse wave velocity correlate with directly measured pulse wave velocity in acute ischemic stroke patients?
Observational (n=200)
Does estimated pulse wave velocity correlate with directly measured pulse wave velocity in acute ischemic stroke patients?
Effect estimate: r=0.560 and r=0.563
p-value: p=<0.001
Estimated pulse wave velocity shows a significant moderate correlation with directly measured PWV in acute ischemic stroke patients, supporting its potential utility as an accessible marker of arterial stiffness.
Estimated PWV should not yet replace measured PWV for stroke risk stratification; leaves open its value pending larger outcome validation.
Background and aims Pulse wave velocity (PWV) is a validated marker of arterial stiffness, an important predictor of cardiovascular risk, and an independent prognostic factor after ischemic stroke. Estimated PWV (ePWV), derived from age and mean blood pressure (MBP), offers a simple alternative to direct PWV measurement. This study aimed to evaluate the correlation between directly measured PWV and ePWV in acute ischemic stroke patients. Methods Two hundred ischemic stroke patients admitted within 24 hours of symptom onset were included. Direct PWV measurement was performed on day 5 of hospitalization. Estimated PWV was calculated as follows: e1-PWV = 9.58748315543126−0.402467539733184×age+4.56020798207263×10-3×age2−2.6207705511664×10-5×age2×MBP+3.1762450559276×10-3×age×MBP−1.83215068503821×10-2×MBP; e2-PWV = 4.62−0.13×age+0.0018×age2+0.0006×age×MBP+0.0284×MBP. Data are presented as median (interquartile range). Pearson’s correlation coefficient was used for statistical analysis. Results Median PWV was 9.7 m/s (8.1–12.3 m/s), median e1-PWV 10.3 m/s (9.0–11.9 m/s), and median e2-PWV 10.3 m/s (9.1–11.7 m/s). Measured PWV showed a significant moderate correlation with e1-PWV (r=0.560, p<0.001) and e2-PWV (r=0.563, p<0.001). Conclusions Estimated PWV calculated using both equations shows a significant moderate correlation with directly measured PWV in acute ischemic stroke patients, supporting its potential clinical utility as an accessible marker of arterial stiffness. Conflict of interest Kamil Kowalczyk: nothing to disclose. Krzysztof Narkiewicz: nothing to disclose. Bartosz Karaszewski: nothing to disclose. Dariusz Gąsecki: nothing to disclose
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Kowalczyk et al. (2026) conducted an observational in Acute ischemic stroke (n=200). Estimated pulse wave velocity (ePWV) vs. Directly measured pulse wave velocity (PWV) was evaluated on Correlation between directly measured PWV and ePWV (r=0.560 and r=0.563, p=<0.001). Estimated pulse wave velocity showed a significant moderate correlation with directly measured pulse wave velocity (r=0.560 and r=0.563, p<0.001) in patients with acute ischemic stroke.
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