Key result
Each standard deviation increase in estimated pulse wave velocity was associated with a 26.3% increased risk of incident cognitive impairment in stroke patients (HR 1.263).
Why the study?
Studies examining the relationship between estimated pulse wave velocity, a surrogate marker of arterial stiffness, and cognitive impairment in stroke patients remain limited.
Is higher estimated pulse wave velocity associated with an increased risk of incident cognitive impairment in stroke patients?
Population
2,003 stroke patients from the China Health and Retirement Longitudinal Study (CHARLS)
Comparison
Estimated pulse wave velocity levels (e.g. highest vs lowest quartile)
Design
Longitudinal cohort study
Authors
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May support ePWV for cognitive risk stratification post-stroke; leaves open need for prospective validation before clinical use.
Cohort (n=2,003)
Yes
Is higher estimated pulse wave velocity associated with an increased risk of incident cognitive impairment in stroke patients?
Hazard Ratio: 1.263 (95% CI 1.154–1.383)
p-value: p=<0.001
Estimated pulse wave velocity is a significant, non-linear predictor of incident cognitive impairment in stroke patients, suggesting its utility as a risk assessment marker.
Xia et al. (2025) conducted a cohort in Stroke (n=2,003). Estimated pulse wave velocity (ePWV) vs. Lower ePWV was evaluated on Incident cognitive impairment (HR 1.263, 95% CI 1.154-1.383, p=<0.001). Each standard deviation increase in estimated pulse wave velocity was associated with a 26.3% increased risk of incident cognitive impairment in stroke patients (HR 1.263).
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