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Evaluate patient and disease characteristics, pharmacological approaches, and outcomes in PACNS patients.

Abstract Number: Esoc2026a2288 Patient- And Disease Characteristics and Pharmacological Approaches in Primary Angiitis of the Central Nervous System (Pacns): Report of Twenty-Five Dutch Cases

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Evaluate patient and disease characteristics, pharmacological approaches, and outcomes in PACNS patients.
Retrospective, single-center cohort study
Analyzed 25 consecutive adult patients diagnosed with PACNS from 2006 to 2025
Assessed baseline characteristics, mortality, relapse rates, and functional outcomes using the modified Rankin Scale.
3 patients (12%) had biopsy-proven diagnosis; others diagnosed using MRI and CSF analysis.
3 patients (12%) died and 9 (36%) had poor outcomes (mRS 3-6); 11 (44%) experienced relapses.
CSF analysis was abnormal in 19 of 22 (86%) patients.

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Retrospective cohort study finds frequent relapses and significant mortality in PACNS patients, highlighting treatment challenges.

Mahabali et al. (2026) studied this question.

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