What question did this study set out to answer?

This analysis aimed to determine the minimal clinically important difference in follow-up infarct volume for favorable outcomes in patients with large infarcts after an acute ischemic stroke.

May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a1647 Minimal Clinically Important Difference of Follow-Up Infarct Volume in Patients With Acute Ischemic Stroke and Large Infarct: A Secondary Analysis of the Tension Trial

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Authors

PHPhilip HeesenUniversity of Zurich OCOlga Ciobanu-CarausBarrow Neurological Institute MHM HillUniversity of Calgary

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Implication

Secondary analysis quantifies infarct volume differences linked to outcomes in acute ischemic stroke patients, indicating implications for treatment effectiveness.

Key Points

This analysis aimed to determine the minimal clinically important difference in follow-up infarct volume for favorable outcomes in patients with large infarcts after an acute ischemic stroke.
Secondary analysis of patients from the TENSION randomized controlled trial.
Measured follow-up infarct volumes on imaging 24 hours post-stroke.
Used adjusted logistic regression to assess the relationships between infarct volume and functional outcomes defined by modified Rankin Scale at 90 days.
In total, 253 patients were included with a median infarct volume of 199.4 mL (IQR 128.8–292.9).
In the EVT group, an increase in infarct volume by 1 mL led to a 0.98 odds ratio for favorable outcomes (95% CI 0.97–0.99; p<0.001).
Reductions of approximately 18 mL, 93 mL, and 185 mL in infarct volume were associated with 1%, 5%, and 10% higher probabilities of achieving favorable outcomes, respectively.

Cite This Study

Heesen et al. (2026) studied this question.

synapsesocial.com/papers/69fd7fb8bfa21ec5bbf083fe https://doi.org/10.1093/esj/aakag023.784

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Implication

Secondary analysis quantifies infarct volume differences linked to outcomes in acute ischemic stroke patients, indicating implications for treatment effectiveness.

Abstract Number: Esoc2026a1647 Minimal Clinically Important Difference of Follow-Up Infarct Volume in Patients With Acute Ischemic Stroke and Large Infarct: A Secondary Analysis of the Tension Trial

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Cite This Study

Abstract Number: Esoc2026a1647 Minimal Clinically Important Difference of Follow-Up Infarct Volume in Patients With Acute Ischemic Stroke and Large Infarct: A Secondary Analysis of the Tension Trial

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Cite This Study

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