What question did this study set out to answer?

This work aims to explore the imaging capabilities and biodistribution of CoMoCAT SWCNTs in vivo, assessing their pharmacokinetics and toxicity.

Multiplex In Vivo Imaging of Biodistribution and Pharmacokinetics of CoMoCAT Single-Walled Carbon Nanotubes

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Randomized trial evaluates biodistribution and pharmacokinetics of CoMoCAT SWCNTs in mice, suggesting safe imaging applications.

This work aims to explore the imaging capabilities and biodistribution of CoMoCAT SWCNTs in vivo, assessing their pharmacokinetics and toxicity.
Used filter-resolved evaluation with band-pass filters at 1000, 1050, and 1100 nm for imaging.
Conducted intraperitoneal administration in BALB/c mice and performed longitudinal whole-body imaging.
Completed a 21-day toxicity study, assessing body mass, behavior, and organ architecture.
Following administration, rapid systemic spread was evident with preferential uptake in reticuloendothelial organs.
Serum kinetics demonstrated monoexponential decay with an elimination half-life of approximately 2.69 h.
No inflammatory or fibrotic lesions observed in organs after toxicity assessment, indicating preserved organ architecture.

Sharma et al. (2026) studied this question.

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View Full Paper

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Authors

Randomized trial evaluates biodistribution and pharmacokinetics of CoMoCAT SWCNTs in mice, suggesting safe imaging applications.

This work aims to explore the imaging capabilities and biodistribution of CoMoCAT SWCNTs in vivo, assessing their pharmacokinetics and toxicity.
Used filter-resolved evaluation with band-pass filters at 1000, 1050, and 1100 nm for imaging.
Conducted intraperitoneal administration in BALB/c mice and performed longitudinal whole-body imaging.
Completed a 21-day toxicity study, assessing body mass, behavior, and organ architecture.
Following administration, rapid systemic spread was evident with preferential uptake in reticuloendothelial organs.
Serum kinetics demonstrated monoexponential decay with an elimination half-life of approximately 2.69 h.
No inflammatory or fibrotic lesions observed in organs after toxicity assessment, indicating preserved organ architecture.

Sharma et al. (2026) studied this question.

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