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May 8, 2026Technology in Cancer Research & TreatmentOpen Access

A New Perspective in Tumor Therapy: Targeting M2-Type Tumor-Associated Macrophages

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Authors

QZQiang ZhangYSY X SunYZYu Zhuang

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Overview

Discusses targeting M2-type tumor-associated macrophages to improve cancer therapies, suggesting innovative immunotherapeutic approaches.

Key Points

  • To assess the role of M2-TAMs in cancer and explore treatment strategies targeting these macrophages.
  • Critical assessment of TAM-targeted approaches
  • Outline of molecular circuits in M2-TAMs-tumor cell interactions
  • Exploration of macrophage diversity in cancer.
  • M2-TAMs promote angiogenesis and metastasis in solid tumors.
  • Diverse functions of TAMs challenge the traditional view of macrophage roles in cancer.
  • Therapeutic strategies targeting M2-TAMs show potential for clinical applications.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69fd7fcdbfa21ec5bbf08732https://doi.org/10.1177/15330338261448345
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The pivotal role of macrophages in tumorigenesis and pioneering cancer immunotherapy across pre-clinical and clinical frontiers2026
  2. 2Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments2025 · 310 citations
  3. 3Tumor-associated macrophages in cancer: from mechanisms to application2025 · 25 citations
  4. 4[Tumor-associated Macrophage: 
Emerging Targets for Modulating the Tumor Microenvironment].2024 · 4 citations
  5. 5Targeting tumor‑associated macrophages: Critical players in tumor progression and therapeutic strategies (Review)2024 · 33 citations