Why the study?
What percentage of depressed adults in routine clinical practice would qualify for antidepressant RCTs based on common exclusion criteria?
What percentage of depressed adults in routine clinical practice would qualify for antidepressant RCTs based on common exclusion criteria?
The vast majority of patients treated for depression in routine clinical practice would be excluded from antidepressant RCTs, suggesting that clinical use often relies on extrapolation from research data.
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Most depressed patients in practice would be excluded from antidepressant RCTs; leaves open generalizability of trial efficacy to routine care.
Zetin et al. (2007) studied this question.
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