What is the current value of MM/PBSA and MM/GBSA methods in drug discovery?

This is the authors' abstract. We don't add key points for this paper.

Introduction 2. MM/PB(GB)SA methods 3.MM/PB(GB)SA applications 3.1. Ligand-binding orientation 3.2. Virtual screening studies 3.3. QM/PB(GB)SA method 3.4. Macromolecular interactions 4. Expert opinion