Key result
Primary aldosteronism is linked to ~4-fold higher stroke risk versus essential hypertension independent of blood pressure.
Why the study?
The rate of cardiovascular events in patients with primary aldosteronism compared to essential hypertension was not well established.
Does primary aldosteronism increase the risk of cardiovascular events compared to essential hypertension?
Population
124 patients with primary aldosteronism and 465 patients with essential hypertension matched for age, gender, and blood pressure
Comparison
Primary aldosteronism vs essential hypertension
Design
Observational case-control study
Authors
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Primary aldosteronism is associated with a significantly higher risk of cardiovascular events than essential hypertension, independent of blood pressure levels.
Observational (n=589)
Does primary aldosteronism increase the risk of cardiovascular events compared to essential hypertension?
Odds Ratio: 4.2 (95% CI 2–8.6)
Absolute Event Rate: 12.9% vs 3.4%
Primary aldosteronism is associated with a significantly higher risk of cardiovascular events than essential hypertension, independent of blood pressure levels.
Milliez et al. (2005) conducted an observational in Primary aldosteronism (n=589). Primary aldosteronism vs. Essential hypertension was evaluated on History of stroke (OR 4.2, 95% CI 2.0-8.6). Primary aldosteronism was associated with a higher risk of stroke compared to essential hypertension (12.9% vs 3.4%; OR 4.2, 95% CI 2.0-8.6), independent of blood pressure.
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