February 1, 1990Circulation Research

Heterogeneous changes in epimyocardial microvascular size during graded coronary stenosis. Evidence of the microvascular site for autoregulation.

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Population

Anesthetized open-chest dogs (n=20)

Comparison

Graded coronary stenosis via screw occluder on… vs Baseline/control state and left circumflex…

Design

Preclinical

Authors

HKHiroshi KanatsukaUniversity of Iowa KLKathryn G. LampingUniversity of Iowa CEC L EasthamUniversity of Iowa

Discussion

Member takes

Implication

Heterogeneous microvascular responses during stenosis are hypothesis-generating; leaves open translation to human coronary autoregulation.

Structured PICO

Population

Anesthetized open-chest dogs (n=20)

Intervention

Graded coronary stenosis (mild: 59 +/- 1 mm Hg, n=20; severe: 38 +/- 1 mm Hg, n=16) via screw occluder on the proximal left anterior descending coronary artery

Comparator

Baseline/control state and left circumflex coronary artery area

Outcome

Epimyocardial microvascular size and myocardial blood flowsurrogate

Coronary autoregulation during graded stenosis involves heterogeneous microvascular responses, with small vessels dilating and large vessels constricting under severe stenosis.

Cite This Study

Kanatsuka et al. (1990) studied this question.

synapsesocial.com/papers/69fe74afe4618ba4162d52ea https://doi.org/10.1161/01.res.66.2.389

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Implication

Heterogeneous microvascular responses during stenosis are hypothesis-generating; leaves open translation to human coronary autoregulation.

Heterogeneous changes in epimyocardial microvascular size during graded coronary stenosis. Evidence of the microvascular site for autoregulation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Heterogeneous changes in epimyocardial microvascular size during graded coronary stenosis. Evidence of the microvascular site for autoregulation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider