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March 1, 1991CirculationOpen Access

Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I thrombolysis in myocardial infarction (TIMI) trial. The TIMI Investigators.

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Why the study?

Does the presence of coronary collateral vessels reduce infarct size in patients with acute myocardial infarction who fail to reperfuse after thrombolytic therapy?

Population

125 patients with acute myocardial infarction from the TIMI Phase I trial who failed to recanalize at 90…

Comparison

Presence of angiographically documented coronary… vs Absence of coronary collateral vessels (n=74)

Design

Cohort

Follow-up

hospital discharge

Authors

GHGabriel B. HabibBaylor College of MedicineJHJacques HeibigHouston MethodistSFSandra FormanCross-Cutting Cardiology

Discussion

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Implication

May refine prognosis after failed thrombolysis; hypothesis-generating for collateral-targeted strategies in AMI.

Structured PICO

Does the presence of coronary collateral vessels reduce infarct size in patients with acute myocardial infarction who fail to reperfuse after thrombolytic therapy?

P
Population
125 patients with acute myocardial infarction from the TIMI Phase I trial who failed to recanalize at 90 minutes after administration of tissue plasminogen activator or streptokinase
I
Intervention
Presence of angiographically documented coronary collateral vessels in the initial hours of myocardial infarct evolution (n=51)
C
Comparator
Absence of coronary collateral vessels (n=74)
O
Outcome
Infarct size as assessed by serial measurements of serum creatine kinase (CK)surrogate

In patients with acute myocardial infarction who fail to reperfuse after thrombolytic therapy, the presence of coronary collaterals is associated with smaller infarct size and better preserved left ventricular function.

Cite This Study

Habib et al. (1991) studied this question.

synapsesocial.com/papers/69fe7956d8476229fea35823https://doi.org/10.1161/01.cir.83.3.739
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Estimation of Infarct Size in Man and its Relation to Prognosis1972 · 714 citations
  2. 2Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge.1987 · 2,256 citations