August 24, 2022Journal of the American Heart Association51 citationsOpen Access
View Full PaperCoronary Artery Disease and Heart Failure With Preserved Ejection Fraction: The ARIC Study
Structured PICO
Is prevalent CAD a risk factor for incident HFpEF?
P
Population
Participants in the ARIC Study
I
Intervention
Prevalent Coronary Artery Disease (CAD)
O
Outcome
Incident Heart Failure with Preserved Ejection Fraction (HFpEF)hard clinical
Prevalent CAD is a significant risk factor for incident HFpEF, a relationship that appears to be largely mediated by echocardiographic alterations such as left ventricular diastolic dysfunction.
Abstract
<0.01). The association of prevalent CAD with incident HFpEF post-Visit 5 was not significant after adjusting for echocardiographic measures, with the greatest attenuation observed for left ventricular diastolic function. Conclusions CAD is a significant risk factor for incident HFpEF after adjustment for demographics and common comorbidities. This relationship is partially accounted for by echocardiographic alterations, particularly left ventricular diastolic function.