Why the study?
Does delayed onset of subendocardial diastolic thinning identify regionally hypoperfused resting myocardium in a canine model of progressive coronary stenosis?
Population
12 dogs with progressive left anterior descending coronary artery stenosis induced by an ameroid occluder
Comparison
M-mode tissue Doppler imaging of the anterior… vs M-mode tissue Doppler imaging of the middle…
Design
Preclinical
Follow-up
1 or 2 weeks
Authors
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May enable earlier ischemia detection in models; leaves open prospective human validation before clinical use.
Does delayed onset of subendocardial diastolic thinning identify regionally hypoperfused resting myocardium in a canine model of progressive coronary stenosis?
Delayed onset of subendocardial thinning on tissue Doppler imaging identifies early-stage myocardial hypoperfusion before the development of local wall motion abnormalities.
Wang et al. (2005) studied this question.
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