Why the study?
Does low-dose chlorthalidone-based antihypertensive treatment reduce major cardiovascular disease events in older patients with isolated systolic hypertension, including those with and without diabetes?
Population
4,736 men and women aged 60 years and older with isolated systolic hypertension, including 583…
Comparison
Low dose chlorthalidone with a step-up to… vs Placebo and any active antihypertensive drugs…
Design
RCT, randomized, Double-blind, placebo-controlled
Follow-up
5 years
Authors
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Supports chlorthalidone-based therapy in older isolated systolic hypertension regardless of diabetes status; confirms consistent relative benefit with larger absolute reduction in diabetes.
Does low-dose chlorthalidone-based antihypertensive treatment reduce major cardiovascular disease events in older patients with isolated systolic hypertension, including those with and without diabetes?
Low-dose chlorthalidone-based therapy significantly reduces major cardiovascular events in older patients with isolated systolic hypertension, yielding a greater absolute risk reduction in those with diabetes.
J. David Curb (1996) studied this question.
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