April 1, 1983Cardiovascular Research

Asynchronous transmural perfusion during coronary reactive hyperaemia

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Population

36 anaesthetised open-chest dogs

Design

Preclinical

Authors

HDH. Fred DowneyUniversity of North Texas GCGeorge J. CrystalIllinois College FBF.A. BashourThe University of Texas Southwestern Medical Center

Discussion

Member takes

Implication

Asynchronous transmural hyperaemia may underestimate vasodilator reserve in testing; leaves open human validation of perfusion dynamics.

Structured PICO

Population

36 anaesthetised open-chest dogs

Intervention

90 s occlusion of the left anterior descending coronary artery to induce reactive hyperaemia

Outcome

Dynamic variation in the transmural distribution of myocardial blood flow (endo/epi flow ratios) estimated from tissue uptake of radioactive microspheressurrogate

The study demonstrates that asynchronous transmural perfusion during coronary reactive hyperaemia is responsible for the prolonged plateau at peak flow and may lead to underestimates of vasodilator capability.

Cite This Study

Downey et al. (1983) studied this question.

synapsesocial.com/papers/69fe79edd8476229fea35ab4 https://doi.org/10.1093/cvr/17.4.200

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