March 1, 1974Cardiovascular Research
Sympathetic and parasympathetic components of reflex tachycardia induced by hypotension in conscious dogs with and without heart failure
Why the study?
Does selective and combined beta-adrenergic and cholinergic blockade affect reflex tachycardia induced by hypotension in conscious dogs?
Population
Conscious, unsedated normal dogs and dogs with congestive heart failure (CHF)
Comparison
Hypotension induced by nitroglycerin and… vs Baseline (before blockades)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Cautions against direct human application; extends dual autonomic mediation evidence in conscious models.
Structured PICO
Does selective and combined beta-adrenergic and cholinergic blockade affect reflex tachycardia induced by hypotension in conscious dogs?
P
Population
Conscious, unsedated normal dogs and dogs with congestive heart failure (CHF)
I
Intervention
Hypotension induced by nitroglycerin and inferior vena caval occlusion (IVCO) before and after selective and combined beta-adrenergic and cholinergic blockades
C
Comparator
Baseline (before blockades)
O
Outcome
Reflex tachycardia (heart rate increase) following hypotensionsurrogate
Reflex tachycardia following hypotension induced by nitroglycerin or IVCO is mediated by a combination of sympathetic and parasympathetic influences in conscious dogs.
Cite This Study
Vatner et al. (1974) studied this question.