Why the study?
Does spironolactone prevent myocardial fibrosis in rat models of arterial hypertension?
Does spironolactone prevent myocardial fibrosis in rat models of arterial hypertension?
Spironolactone prevents myocardial fibrosis and scarring in experimental models of hypertension, suggesting aldosterone plays a key role in cardiac collagen accumulation independent of blood pressure.
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Spironolactone's antifibrotic effects remain preclinical in rat models; leaves open clinical translation to human hypertension.
Brilla et al. (1992) studied this question.