Single Dose Captopril as a Diagnostic Test for Primary Aldosteronism*

31 subjects on an unrestricted diet, including 9 normotensive subjects, 10 patients with essential hypertension (EH), and 12 patients with primary aldosteronism (including 5 with idiopathic hyperaldosteronism and others with an aldosterone-producing adenoma).

Single dose of captopril 25 mg.

Comparison of responses across the three different subject groups (normotensive, essential hypertension, primary aldosteronism).

Plasma aldosterone concentration and aldosterone to renin ratio 2 hours after captopril administration.surrogate