Catheter‐Based Renal Denervation for Resistant Hypertension: Rationale and Design of the SYMPLICITY HTN‐3 Trial
Why the study?
Does catheter-based bilateral renal denervation reduce office-based systolic blood pressure in patients with resistant hypertension?
Population
Patients with uncontrolled hypertension despite compliance with at least 3 antihypertensive medications of…
Comparison
Catheter-based bilateral renal denervation vs Masked procedure
Design
Other, prospective, randomized, masked procedure, single-blind trial
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
Protocol for SYMPLICITY HTN-3 released; leaves open whether renal denervation reduces BP in resistant hypertension.
Structured PICO
Does catheter-based bilateral renal denervation reduce office-based systolic blood pressure in patients with resistant hypertension?
P
Population
Patients with uncontrolled hypertension despite compliance with at least 3 antihypertensive medications of different classes (at least one of which is a diuretic) at maximal tolerable doses
I
Intervention
Catheter-based bilateral renal denervation
C
Comparator
Masked procedure
O
Outcome
Change in office-based systolic blood pressure from baseline to 6 monthssurrogate
This manuscript describes the rationale and design of the SYMPLICITY HTN-3 trial evaluating renal denervation for resistant hypertension.
Cite This Study
Kandzari et al. (2012) studied this question.