Key result
Contrast volume-to-CrCl ratio ≥3.7 is linked to a ~4-fold higher risk of post-PCI nephropathy.
Why the study?
The volume-to-creatinine clearance ratio (V/CrCl) has been proposed as a pharmacokinetic measure to predict early serum creatinine increase after PCI but required validation.
Does a volume-to-creatinine clearance ratio (V/CrCl) ≥ 3.7 predict an early increase in serum creatinine in patients undergoing PCI?
Observational (n=3,179)
Does a volume-to-creatinine clearance ratio (V/CrCl) ≥ 3.7 predict an early increase in serum creatinine in patients undergoing PCI?
Odds Ratio: 3.84 (95% CI 2–7.3)
p-value: p=< 0.001
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A volume-to-creatinine clearance ratio ≥3.7 is a significant and independent predictor of early abnormal increase in serum creatinine (contrast-induced nephropathy) after PCI.
Laskey et al. (2007) conducted an observational in Patients undergoing percutaneous coronary intervention (PCI) (n=3,179). Volume of contrast media to creatinine clearance ratio (V/CrCl) ≥3.7 vs. V/CrCl < 3.7 was evaluated on Early increase in serum creatinine of >0.5 mg/dl by 24 to 48 hours (OR 3.84, 95% CI 2.0 to 7.3, p=< 0.001). A volume-to-creatinine clearance ratio ≥3.7 was significantly associated with an early abnormal increase in serum creatinine after PCI (OR 3.84; 95% CI 2.0-7.3; p<0.001).
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