What question did this study set out to answer?

The study aims to measure the changes in myocardial wall thickness during different phases of the cardiac cycle.

June 1, 1964Circulation ResearchOpen Access

Myocardial Mural Thickness During the Cardiac Cycle

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Isovolumic wall thickening may augment ejection; leaves open translation to human ventricular mechanics.

The study aims to measure the changes in myocardial wall thickness during different phases of the cardiac cycle.
Measured left ventricular wall thickness in ten dogs using a specially designed transducer.
Assessed thickness changes during the isovolumic phase and ejection period of systole.
Administered norepinephrine at 0.001 mg/kg per minute to evaluate its effect on thickness.
Thickness during isovolumic phase increased by 11%, rising to 20% with norepinephrine.
Average increase during ejection period was 10% without norepinephrine and 15% with it.
Measurements of transverse and longitudinal epicardial strains were consistent with myocardial thickness strain.

Feigl et al. (1964) studied this question.

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