Primary cardiac angiosarcoma — hybrid therapy using coronary microembolization with coiling

Q: What does this research mean for the field?

Coronary artery microembolization combined with coiling can achieve local tumor reduction and temporary local control in unresectable or refractory primary cardiac angiosarcoma. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Edward Pietrzyk; Anna Polewczyk; Michał Spałek; Adriana Złahoda-Huzior; Łukasz Rekść; Paulina Krawczyk; Dariusz Dudek

doi:10.33963/v.phj.112496

May 5, 2026Kardiologia PolskaOpen Access

Primary cardiac angiosarcoma — hybrid therapy using coronary microembolization with coiling

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Key Points

To evaluate the feasibility and efficacy of hybrid therapy combining surgery, chemotherapy, and superselective coronary microembolization with coiling for inoperable primary cardiac angiosarcoma.
Case report of a 54-year-old male with an unresectable right atrial angiosarcoma (grade G3) invading adjacent cardiac and venous structures.
Intervention involved partial surgical debulking, two cycles of chemotherapy with doxorubicin and dacarbazine, and subsequent superselective transarterial embolization.
Embolization was performed via radial access using HydroPearl microspheres (200 µm ± 75 µm) and an Azur circumflex coil (3 mm/8 cm) to occlude feeding branches of the circumflex and right coronary arteries.
Following chemotherapy failure where the tumor regrew to 112 × 94 mm, superselective microembolization achieved local reduction of the mass to 63 × 36 mm at 1 month.
Echocardiography showed no significant local tumor progression 5 months after the procedure.
The patient ultimately died 12 months after initial diagnosis due to widespread hepatic and pulmonary metastases.

Structured PICO

P

Population

A 54-year-old man, former smoker with hyperlipidaemia, presenting with a large primary cardiac angiosarcoma (grade G3) in the right atrium with invasion of the inferior vena cava.

I

Intervention

Hybrid therapy comprising partial surgical debulking, chemotherapy (doxorubicin and dacarbazine), and superselective transarterial embolization of the coronary artery feeding the tumor using HydroPearl microspheres (200 µm ± 75 µm) and an Azur circumflex coil.

O

Outcome

Tumor size reduction and clinical improvementsurrogate

Superselective transarterial embolization of the coronary artery feeding a primary cardiac angiosarcoma can reduce tumor mass and provide clinical improvement as part of a hybrid therapeutic approach.

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Implication

Hypothesis-generating for hybrid embolization in primary cardiac angiosarcoma; leaves open survival benefit and should not alter practice.

Abstract

Primary cardiac sarcomas are extremely rare malignant tumors, accounting for 0.001% to 0.3%

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Cite This Study

Pietrzyk et al. (2026) studied this question.

synapsesocial.com/papers/69fece83b9154b0b82875f82 https://doi.org/10.33963/v.phj.112496

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Primary cardiac angiosarcoma — hybrid therapy using coronary microembolization with coiling

Key Points

Structured PICO

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Implication

Abstract

Discussion

Cite This Study

Primary cardiac angiosarcoma — hybrid therapy using coronary microembolization with coiling

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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