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This review aims to synthesize evidence on the neural substrates of apathy in Parkinson's disease using neuroimaging studies.

Neural Substrates of Apathy in Parkinson’s Disease: a systematic review of Structural and Functional Neuroimaging Studies

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Systematic review investigates neural correlates of apathy in Parkinson’s disease, indicating distinct mechanisms.

This review aims to synthesize evidence on the neural substrates of apathy in Parkinson's disease using neuroimaging studies.
Systematic review conducted following PRISMA guidelines.
Studies assessed included structural MRI, resting-state functional MRI, diffusion tensor imaging, and PET/SPECT.
Reviews compared findings between PD patients with and without apathy and healthy controls.
Apathy in PD is associated with reduced gray matter volume in the dorsolateral and inferior frontal gyri, anterior cingulate cortex, and nucleus accumbens.
Altered functional connectivity within fronto-striatal-limbic networks correlates with apathy severity.
Evidence of heterogeneous neurobiological mechanisms suggests variable involvement of frontal, striatal, and limbic circuits.

Marafioti et al. (2026) studied this question.

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