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The aim is to understand the neural correlates of apathy in Parkinson’s disease by examining brain network disruptions.

Network localization of functional and structural correlates of apathy in Parkinson’s disease

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The aim is to understand the neural correlates of apathy in Parkinson’s disease by examining brain network disruptions.
Conducted a systematic review of whole-brain studies on patients with and without apathy in Parkinson’s disease.
Integrated significant peak coordinates from 24 studies using functional connectivity network mapping.
Utilized resting-state functional magnetic resonance imaging data from 1,093 healthy participants to quantify spatial overlaps.
Identified a common functional connectivity network associated with apathy in Parkinson’s disease.
Key regions included the bilateral inferior frontal gyrus and the bilateral anterior insula among others.
The apathy-associated network showed the greatest overlap with the ventral attention network, subcortical network, and frontoparietal network.

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Systematic review analyzes brain networks related to apathy in Parkinson’s disease, indicating a unified approach.

Yang et al. (2026) studied this question.

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