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Association between brain iron deposition and pure apathy in Parkinson’s disease: a cross-sectional quantitative susceptibility mapping imaging study

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Cross-sectional analysis finds higher brain iron in PD patients with apathy, suggesting a neurodegenerative link.

Patients with Parkinson's disease demonstrated increased brain iron deposition compared to healthy controls.
Positive correlation between Apathy Scale score and iron levels in specific brain regions was observed in PD with apathy.
Quantitative susceptibility mapping was employed to detect brain iron deposition in study participants.
Abnormal iron deposition may indicate mechanisms involved in apathy for patients with Parkinson's disease.

Zhang et al. (2025) studied this question.

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