What question did this study set out to answer?

The study aims to explore how genetic risk influences the relationship between sleep disturbances and memory deficits in older women at risk for Alzheimer's disease.

May 9, 2026The Journal of Prevention of Alzheimer s DiseaseOpen Access

Sleep complaints and genetic risk of Alzheimer’s disease in older women: associations with memory and tau deposition

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Authors

KLKitty K. Lui XWXin Wang MDMelanie A Dratva

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Overview

Randomized trial examines how genetic risk affects sleep's impact on memory and tau burden in older women, suggesting new intervention insights.

Key Points

The study aims to explore how genetic risk influences the relationship between sleep disturbances and memory deficits in older women at risk for Alzheimer's disease.
Examined older women (≥65 years) from the Women Inflammation Tau Study.
Participants completed the Pittsburgh Sleep Quality Index, Rey Auditory Learning Test, and Brief Visuospatial Memory Test-Revised.
Analyzed PSQI global scores and polygenic hazard score interactions on memory and tau burden.
Poor sleep correlated with worse visual memory and increased tau deposition in higher genetic risk women (p<0.04).
No significant associations found for verbal memory or tau in other Braak regions.
Findings suggest sleep difficulties might increase Alzheimer’s risk, particularly in older women.

Cite This Study

Lui et al. (2026) studied this question.

synapsesocial.com/papers/69fecf49b9154b0b82876440 https://doi.org/10.1016/j.tjpad.2026.100581

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May 9, 2026The Journal of Prevention of Alzheimer s DiseaseOpen Access

Sleep complaints and genetic risk of Alzheimer’s disease in older women: associations with memory and tau deposition

View Full Paper

Ask AI

Bookmark

Authors

KLKitty K. Lui XWXin Wang MDMelanie A Dratva

Discussion

Member takes

Overview

Randomized trial examines how genetic risk affects sleep's impact on memory and tau burden in older women, suggesting new intervention insights.

Key Points

The study aims to explore how genetic risk influences the relationship between sleep disturbances and memory deficits in older women at risk for Alzheimer's disease.
Examined older women (≥65 years) from the Women Inflammation Tau Study.
Participants completed the Pittsburgh Sleep Quality Index, Rey Auditory Learning Test, and Brief Visuospatial Memory Test-Revised.
Analyzed PSQI global scores and polygenic hazard score interactions on memory and tau burden.
Poor sleep correlated with worse visual memory and increased tau deposition in higher genetic risk women (p<0.04).
No significant associations found for verbal memory or tau in other Braak regions.
Findings suggest sleep difficulties might increase Alzheimer’s risk, particularly in older women.

Cite This Study

Lui et al. (2026) studied this question.

synapsesocial.com/papers/69fecf49b9154b0b82876440 https://doi.org/10.1016/j.tjpad.2026.100581

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