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May 9, 2026Cancer Biomarkers

Detection of methylated SEPT9 DNA in peripheral blood for diagnosis of colorectal cancer

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Authors

MLMengjie LinHCHong ChenCJCaifeng Jiang

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Overview

Case-control study detects methylated SEPT9 in blood, indicating a non-invasive CRC diagnostic method.

Key Points

  • This study aims to evaluate the effectiveness of detecting methylated SEPT9 DNA in blood samples as a diagnostic tool for colorectal cancer.
  • Single-center case-control study with 119 participants (79 CRC patients, 20 with adenomas, 20 controls)
  • Blood samples analyzed for methylated SEPT9 DNA using droplet digital polymerase chain reaction (ddPCR)
  • Conducted from May 2023 to March 2025.
  • Sensitivity of mSEPT9 detection for CRC was 68.35% and specificity was 95.00%
  • Positive rates for left-sided CRC were 65.31% and for right-sided CRC were 72.41% (p > 0.05)
  • Combining mSEPT9 detection with CEA and CA19-9 raised the positive detection rate to 82.67%.

Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/69fecfe9b9154b0b82876dd1https://doi.org/10.1177/18758592261449027
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