Porphyrinic MOF-Confined Nanozyme Hydrogel with CuS-Mediated Photoregulation for Infected Wound Healing

-Fe) redox activity for near-infrared (NIR)-activated targeted therapy. The metal-organic framework integrates photothermal, photodynamic, and nanozyme redox mechanisms to modulate ROS in hypoxic environments. This injectable, self-healing hydrogel conforms to wound surfaces, adheres to tissue, and remains localized at the injury site, enabling precise therapy upon NIR irradiation. In vitro and in vivo experiments demonstrate that the integrated photothermal, photodynamic, and nanozyme redox activities reduce bacterial load, attenuate inflammation, and restore oxidative balance in wounds. As a result, hydrogel promotes granulation tissue formation, collagen deposition, and skin regeneration in infected wound models.