Key result
Arterial hypertension develops as a multifactorial process driven by sequential and interconnected homeostatic dysfunctions.
Why the study?
Arterial hypertension is a major risk factor for cardiovascular diseases and mortality, prompting an analysis of its pathogenesis and impaired physiological regulatory mechanisms.
This review highlights that arterial hypertension pathogenesis involves multifactorial impairment of physiological regulatory mechanisms including the sympathetic nervous system, RAAS, kidneys, and endothelial function.
Arterial hypertension (AH) is one of the most pressing problems in modern medicine, serving as a major risk factor for cardiovascular diseases and mortality rates. This scientific article aims to analyze the pathogenesis of arterial hypertension and the impairment of physiological regulatory mechanisms that control blood pressure (sympathetic nervous system, renin-angiotensin-aldosterone system, kidneys, and endothelial function). The elevation of blood pressure is a multifactorial process resulting from sequential and interconnected dysfunctions within the homeostatic system.
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Toʻychiyeva et al. (2026) conducted a review in Arterial hypertension. The elevation of blood pressure in arterial hypertension is a multifactorial process resulting from sequential and interconnected dysfunctions within the homeostatic system.
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