Key result
Hypertension involves macrovascular and microvascular alterations driven by precursor endothelial dysfunction.
Revisiting the pathophysiology of hypertension to include the precursor role of endothelial dysfunction and vascular alterations provides new insights for preventive and therapeutic strategies.
No takes yet. Share an insight, caveat, or question.
Endothelial assessment remains investigational in hypertension; leaves open whether targeting dysfunction alters macrovascular outcomes.
Yannoutsos et al. (2013) conducted a review in Hypertension. The pathophysiology of hypertension involves both macrovascular and microvascular alterations, with endothelial dysfunction playing a precursor role in microvascular changes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: