Key result
Primary hypertension is driven by polygenic predisposition, environmental effects, and structural upward resetting of the cardiovascular system, which becomes increasingly dominant with age.
This review outlines the multifactorial pathogenesis of primary hypertension, emphasizing the progressive structural upward resetting of the cardiovascular system that becomes increasingly dominant and treatment-resistant with age.
No takes yet. Share an insight, caveat, or question.
May explain age-related treatment resistance in primary hypertension; leaves open whether targeting structural resetting improves outcomes.
Bj rn Folkow (1993) conducted a review in Hypertension. Primary hypertension is driven by polygenic predisposition, environmental effects, and structural upward resetting of the cardiovascular system, which becomes increasingly dominant with age.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: