What is the clinical evidence from this study?

Study design: Review. Population: Hypertension.

What does this research mean for the field?

Microvascular structural alterations in hypertension predict the onset of cardio-cerebrovascular events and interact with large artery damage in a vicious cycle to exaggerate arterial damage. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To review the hemodynamic consequences of microvascular structural remodeling in hypertension and clarify its interactions with large conductance arteries.

February 19, 2017American Journal of Hypertension

Hemodynamic Consequences of Changes in Microvascular Structure

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Key result

Microvascular structural alterations in hypertension may predict the onset of cardio-cerebrovascular events and interact with large artery damage to exaggerate arterial damage.

Key Points

To review the hemodynamic consequences of microvascular structural remodeling in hypertension and clarify its interactions with large conductance arteries.
Narrative review assessing structural changes in small resistance arteries and their timing in hypertensive disease.
Analysis of mechanical and morphological cross-talk between the microcirculation and large conductance vessels.
An increased media-to-lumen ratio in small resistance arteries increases vascular resistance and compromises local tissue perfusion.
Structural microvascular alterations predict target organ damage and future cardio-cerebrovascular events.
Bidirectional interactions between small vessel remodeling and large artery stiffness establish a vicious cycle that sustains elevated blood pressure.

Structured PICO

Population

Patients with hypertension

Structural alterations in the microcirculation play a key role in the pathophysiology of hypertension and may predict future cardiovascular events.

Discussion

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Implication

May support microvascular assessment for risk stratification in hypertension; leaves open prospective validation of integrated macro-microvascular strategies.

Cite This Study

Rizzoni et al. (2017) conducted a review in Hypertension. Microvascular structural alterations in hypertension may predict the onset of cardio-cerebrovascular events and interact with large artery damage to exaggerate arterial damage.

synapsesocial.com/papers/6a15cccea2352da34782ec8a https://doi.org/10.1093/ajh/hpx032

Topics

Hypertension management

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Implication

May support microvascular assessment for risk stratification in hypertension; leaves open prospective validation of integrated macro-microvascular strategies.

Hemodynamic Consequences of Changes in Microvascular Structure

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Hemodynamic Consequences of Changes in Microvascular Structure

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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