What question did this study set out to answer?

The objective is to explore the relationship between reactivity and structural changes of small blood vessels in hypertension.

February 1, 1992HypertensionOpen Access

Reactivity of small blood vessels in hypertension: relation with structural changes. State of the art lecture.

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Population

Hypertensive rats (renal and deoxycorticosterone acetate-salt models) and hypertensive humans

Design

Review

Authors

ESErnesto L. SchiffrinMedical Council of Canada

Discussion

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Implication

Structural remodeling may sustain hypertension via amplified vasoconstriction; leaves open whether targeting media/lumen ratio improves outcomes.

Key Points

The objective is to explore the relationship between reactivity and structural changes of small blood vessels in hypertension.
Review of morphological and functional alterations in small blood vessels with a focus on mesenteric small arteries and arterioles.
Comparison of structural changes in hypertensive rats and humans, including lumen diameter and media/lumen ratio.
Reduced external and lumen diameter in mesenteric small arteries of hypertensive rats were observed.
Increased media/lumen ratio and thickening of the vessel wall were found in hypertensive conditions.
Decreased vasomotion amplitude and rarefaction of blood vessels in arterioles contributed to maintaining elevated blood pressure.

Structured PICO

Population

Hypertensive rats (renal and deoxycorticosterone acetate-salt models) and hypertensive humans

Outcome

Morphological and functional alterations of small blood vesselssurrogate

Structural changes in small resistance arteries, such as reduced lumen diameter and increased media thickness, amplify the pressor effect of vasoconstrictors in hypertension.

Cite This Study

Ernesto L. Schiffrin (1992) studied this question.

synapsesocial.com/papers/6a6f9be635aa2c282ce0f38f https://doi.org/10.1161/01.hyp.19.2_suppl.ii1-a

Topics

Hypertension management

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Implication

Structural remodeling may sustain hypertension via amplified vasoconstriction; leaves open whether targeting media/lumen ratio improves outcomes.

Reactivity of small blood vessels in hypertension: relation with structural changes. State of the art lecture.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Reactivity of small blood vessels in hypertension: relation with structural changes. State of the art lecture.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider