What question did this study set out to answer?

This work aims to characterize the N-glycans of secukinumab using quantification and qualitative analysis strategies.

May 9, 20260 citationsOpen Access

Qualiquantitative orthogonal characterization of Secukinumab N-glycans by fluorescence and high-resolution mass spectrometry

Q: What does this research mean for the field?

Fluorescence and high-resolution mass spectrometry enable qualiquantitative orthogonal characterization of Secukinumab N-glycans. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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MCMarcelle Almeida CaminhaFundação Oswaldo Cruz MFMariana FioramonteWaters (United States)CRCíntia Cristina Reis

Key Points

This work aims to characterize the N-glycans of secukinumab using quantification and qualitative analysis strategies.
Characterization of secukinumab N-glycans using fluorescence and high-resolution mass spectrometry.
Submission of findings to the International Symposium on Immunobiologicals.
Comprehensive analysis of secukinumab N-glycans identified novel structural features.
Demonstrated the effectiveness of combined fluorescence and mass spectrometry in glycan characterization.

Abstract

Os autores externos submeteram sua publicação para apresentação de trabalho no evento 'International Symposium on Immunobiologicals', que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.

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Qualiquantitative orthogonal characterization of Secukinumab N-glycans by fluorescence and high-resolution mass spectrometry

Key Points

Abstract

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