First Clinical Results of Novel Haemodynamic Simulation Software for Patient-Specific Qp:Qs Quantification in Patients with Atrial Septal Defect Using Routine 2D Echocardiographic Data

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Atrial septal defect (n=94). Intervention: Software-based Qp:Qs quantification (haemodynamic simulation model) vs. Conventional Doppler-derived Qp:Qs quantification. Primary outcome: Mean Qp:Qs.

Florian Gross; Robert Dragendorf; Teresa Lerach; Alexandra Hinke; Felix Berger; Raphael Seiler; S. Ovrutskiy

doi:10.3390/jcm15093540

May 6, 2026Journal of Clinical MedicineOpen Access

First Clinical Results of Novel Haemodynamic Simulation Software for Patient-Specific Qp:Qs Quantification in Patients with Atrial Septal Defect Using Routine 2D Echocardiographic Data

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Key result

Software-based Qp:Qs simulation shows no systematic difference versus conventional Doppler estimates.

n=94

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Why the study?

Conventional echocardiographic Qp:Qs estimation in ASD is limited by operator dependency, Doppler alignment sensitivity, and measurement errors, prompting evaluation of simulation-based haemodynamic modelling.

Does software-based haemodynamic simulation modelling provide comparable Qp:Qs quantification to conventional Doppler echocardiography in patients with atrial septal defect?

Study Design

Type

Observational (n=94)

Multicenter

No

Structured PICO

Does software-based haemodynamic simulation modelling provide comparable Qp:Qs quantification to conventional Doppler echocardiography in patients with atrial septal defect?

P

Population

94 patients (98 echocardiographic examinations) with isolated secundum atrial septal defect (ASD) undergoing defect closure between 2018 and 2024 at a single centre.

I

Intervention

Software-based Qp:Qs quantification using a three-dimensional haemodynamic simulation model based on cardiac chamber geometry and physiological parameters derived from routine 2D echocardiographic data.

C

Comparator

Conventional Doppler-derived Qp:Qs quantification using pulmonary and aortic valve diameter and velocity-time integral measurements.

O

Outcome

Agreement between conventional Doppler-derived and software-based Qp:Qs quantification, assessed via mean comparison and Bland-Altman analysis with a predefined ± 20% deviation threshold.surrogate

Main Result

Absolute Event Rate: 1.73% vs 1.83%

A novel 3D haemodynamic simulation software provides feasible Qp:Qs estimates in ASD patients with no systematic difference compared to conventional Doppler methods, though only 53% of cases fell within a 20% deviation range.

Limitations

Retrospective single-centre design
Requires prospective validation against invasive haemodynamic reference standards
Retrospective design
Single-centre study
Lack of invasive haemodynamic reference standard

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Implication

Requires caution in noninvasive Qp:Qs for ASD decisions; leaves open simulation modelling's role pending outcome validation.

Abstract

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Discussion

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Cite This Study

Gross et al. (2026) conducted an observational in Atrial septal defect (n=94). Software-based Qp:Qs quantification (haemodynamic simulation model) vs. Conventional Doppler-derived Qp:Qs quantification was evaluated on Mean Qp:Qs. Software-based haemodynamic simulation for Qp:Qs quantification yielded a mean of 1.73, showing no systematic difference compared to conventional Doppler-derived estimates (mean 1.83).

synapsesocial.com/papers/69fed090b9154b0b82877afb https://doi.org/10.3390/jcm15093540

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First Clinical Results of Novel Haemodynamic Simulation Software for Patient-Specific Qp:Qs Quantification in Patients with Atrial Septal Defect Using Routine 2D Echocardiographic Data

Figures

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

First Clinical Results of Novel Haemodynamic Simulation Software for Patient-Specific Qp:Qs Quantification in Patients with Atrial Septal Defect Using Routine 2D Echocardiographic Data

Figures

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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