Experimental study reveals that matrix metalloproteinase-9 deficiency exacerbates abdominal aortic aneurysms in mice, suggesting an unexpected protective role against vascular rupture.
BACKGROUND: This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA). METHODS AND RESULTS: mice. MMP-9 deficiency led to AAA formation in the absence of AngII, and augmented AngII-induced aortic rupture and AAA incidence. CONCLUSIONS: MMP-9 deficiency augmented AngII-induced AAA.
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Howatt et al. (2017) studied this question.
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