Key result
Mice deficient in MMP-9 or MMP-2 showed no aneurysm formation 10 weeks after CaCl2 treatment, whereas wild-type mice showed an average 74% and 52% increase in aortic diameter, respectively.
Why the study?
Does deficiency in MMP-2 or MMP-9 prevent CaCl2-induced abdominal aortic aneurysm formation in mice?
Does deficiency in MMP-2 or MMP-9 prevent CaCl2-induced abdominal aortic aneurysm formation in mice?
Absolute Event Rate: 8% vs 74%
p-value: p=<0.01
Macrophage-derived MMP-9 and mesenchymal cell MMP-2 are both required and work in concert to produce abdominal aortic aneurysms in a murine model.
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MMP-2/9 essential for experimental AAA; human translation and therapeutic targeting remain untested.
Longo et al. (2002) studied Abdominal aortic aneurysm. MMP-9 or MMP-2 genetic deficiency (MMP-9KO or MMP-2KO) vs. Wild-type mice was evaluated on Increase in aortic diameter (p=<0.01). Mice deficient in MMP-9 or MMP-2 showed no aneurysm formation 10 weeks after CaCl2 treatment, whereas wild-type mice showed an average 74% and 52% increase in aortic diameter, respectively.
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