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October 28, 2019British Journal of PharmacologyOpen Access

Ang-(1-7) reduced the incidence and severity of AAA induced by Ang II infusion by inhibiting macrophage infiltration, attenuating inflammatory markers, and decreasing SMC apoptosis.

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Why the study?

To test the hypothesis that angiotensin-(1-7) may attenuate abdominal aortic aneurysm by inhibiting vascular inflammation, extracellular matrix degradation, and smooth muscle cell apoptosis.

Does angiotensin-(1-7) reduce angiotensin II-induced abdominal aortic aneurysms in ApoE-/- mice?

Population

Ang II-infused ApoE -/- mice and cultured SMCs or macrophages

Comparison

Ang II + Ang-(1-7) vs control, Ang II alone, and additions of A779 or PD123319

Design

Preclinical animal and in vitro experimental study

Authors

FXFei XueJYJianmin YangJCJing Cheng

Discussion

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Overview

Hypothesis-generating for Ang-(1-7) in AAA; prospective trials needed before clinical adoption.

Structured PICO

Does angiotensin-(1-7) reduce angiotensin II-induced abdominal aortic aneurysms in ApoE-/- mice?

P
Population
Apolipoprotein E-knockout (ApoE-/-) mice with abdominal aortic aneurysm (AAA) induced by angiotensin II (Ang II) infusion, and cultured smooth muscle cells (SMCs) or macrophages.
I
Intervention
Angiotensin-(1-7) [Ang-(1-7)]
C
Comparator
Control, Ang II alone, Ang II + Ang-(1-7) + A779, and Ang II + Ang-(1-7) + PD123319
O
Outcome
Incidence and severity of abdominal aortic aneurysm (AAA)surrogate

In a preclinical model, angiotensin-(1-7) attenuated angiotensin II-induced abdominal aortic aneurysms, suggesting a potential novel therapeutic approach for AAA.

Cite This Study

Xue et al. (2019) studied this question.

synapsesocial.com/papers/6a821bc4e282fcaf79c69ed7https://doi.org/10.1111/bph.14906
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Also Consider

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  3. 3Efficacy and Mechanism of Angiotensin II Receptor Blocker Treatment in Experimental Abdominal Aortic Aneurysms2012 · 79 citations
  4. 417β-Estradiol Attenuates Development of Angiotensin II–Induced Aortic Abdominal Aneurysm in Apolipoprotein E–Deficient Mice2003 · 103 citations
  5. 5One amino acid change of Angiotensin II diminishes its effects on abdominal aortic aneurysm2019 · 61 citations