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November 1, 2023Bioscience ReportsOpen Access

Treatment with Ang 1-7 led to suppression of Ang II-induced aortic dilatation in the abdominal aorta and attenuated smooth muscle cell death by mitigating mitochondrial fission, ROS generation, and pro-apoptotic proteins.

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Why the study?

Abdominal aortic aneurysm is characterized by aortic dilatation and rupture, and the effects of Ang 1-7 and its molecular mechanisms in this setting remained to be determined.

Does Angiotensin 1-7 prevent abdominal aortic dilatation and smooth muscle cell death in a murine model of abdominal aortic aneurysm?

Population

Eight- to 10-week-old apolipoprotein E-deficient mice infused with Ang II

Comparison

Ang 1-7 (0.576 mg/kg/day, i.p.) vs no Ang 1-7

Design

Preclinical animal study

Authors

AJAnshul S. JadliKGKarina Pereira GomesNBNoura Ballasy

Discussion

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Overview

Hypothesis-generating for Ang 1-7 in murine AAA; leaves open human translation and clinical trials.

Structured PICO

Does Angiotensin 1-7 prevent abdominal aortic dilatation and smooth muscle cell death in a murine model of abdominal aortic aneurysm?

P
Population
8- to 10-week-old apolipoprotein E-deficient mice (ApoEKO) infused with Ang II (1.44 mg/kg/day, s.c.) as a murine model of abdominal aortic aneurysm
I
Intervention
Angiotensin 1-7 (0.576 mg/kg/day, i.p.)
C
Comparator
Ang II-infused ApoEKO mice not receiving Angiotensin 1-7
O
Outcome
Abdominal aortic dilatation and extracellular matrix remodeling assessed by echocardiographic and histological analysessurrogate

In a murine model of abdominal aortic aneurysm, Angiotensin 1-7 suppressed aortic dilatation and smooth muscle cell apoptosis, suggesting a potential therapeutic pathway to halt AAA progression.

Cite This Study

Jadli et al. (2023) studied this question.

synapsesocial.com/papers/6a76b82f98f24dbf64bd4fddhttps://doi.org/10.1042/bsr20230718
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin‐(1‐7) mitigated angiotensin II‐induced abdominal aortic aneurysms in apolipoprotein E‐knockout mice2019 · 34 citations
  2. 2Angiotensin-(1-7) Protects against the Development of Aneurysmal Subarachnoid Hemorrhage in Mice2015 · 41 citations
  3. 3Vasoprotective and Atheroprotective Effects of Angiotensin (1-7) in Apolipoprotein E–Deficient Mice2010 · 152 citations
  4. 4Angiotensin 1–7 Reduces Mortality and Rupture of Intracranial Aneurysms in Mice2014 · 46 citations
  5. 5Dose-Dependent Bidirectional Effect of Angiotensin IV on Abdominal Aortic Aneurysm via Variable Angiotensin Receptor Stimulation2015 · 24 citations