Why the study?
Does angiotensin-(1-7) inhibit atherosclerotic lesion formation and enhance plaque stability in ApoE(-/-) mice?
Population
ApoE mice fed a high-fat diet and chronic angiotensin II infusion; vascular smooth muscle cells and…
Design
Preclinical
Authors
Loading...
Ang-(1-7) merits testing in advanced models; leaves open translation to human atherosclerosis therapy.
Does angiotensin-(1-7) inhibit atherosclerotic lesion formation and enhance plaque stability in ApoE(-/-) mice?
Angiotensin-(1-7) inhibits early atherosclerotic lesions and increases plaque stability in a preclinical mouse model, suggesting a potential therapeutic target for atherosclerosis.
Yang et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: