Key result
Treatment with 17beta-estradiol significantly reduced the incidence of Angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice from 90% to 42%.
Why the study?
Does 17beta-estradiol prevent Angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice?
Population
Apolipoprotein E-deficient mice infused with Angiotensin II (1.44 mg/kg per d for 1 month), n=39
Comparison
17beta-estradiol vs Angiotensin II infusion alone (no E2 treatment)
Design
Preclinical
Follow-up
1 month
Authors
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Extends evidence of hormonal modulation in experimental AAA; leaves open translation to clinical prevention.
Does 17beta-estradiol prevent Angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice?
Absolute Event Rate: 42% vs 90%
17beta-estradiol attenuates the development of Angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-deficient mice, likely via inhibition of proinflammatory gene expression.
Martin-McNulty et al. (2003) studied Angiotensin II-induced abdominal aortic aneurysm (n=39). 17beta-estradiol (E2) vs. Angiotensin II alone was evaluated on Incidence of abdominal aortic aneurysm (AAA). Treatment with 17beta-estradiol significantly reduced the incidence of Angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice from 90% to 42%.
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