Treatment with 17beta-estradiol significantly reduced the incidence of Angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice from 90% to 42%.
Does 17beta-estradiol prevent Angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice?
17beta-estradiol attenuates the development of Angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-deficient mice, likely via inhibition of proinflammatory gene expression.
Absolute Event Rate: 42% vs 90%
OBJECTIVE: Angiotensin II (Ang II) promotes vascular inflammation, accelerates atherosclerosis, and induces abdominal aortic aneurysm (AAA). These changes were associated with activation of nuclear factor (NF)-kappaB-mediated induction of proinflammatory genes. The incidence of AAA in this model was higher in male than in female mice, and the vascular effects of estrogen may be associated with anti-inflammatory actions. The present study was undertaken to test the hypothesis that estrogen can attenuate Ang II-induced AAA in apolipoprotein E-deficient mice via its anti-inflammatory mechanism. METHODS AND RESULTS: Infusion of Ang II (1.44 mg/kg per d for 1 month) induced AAA in 90% of the animals (n=20) with an expansion of the suprarenal aorta (diameter 1.9+/-0.14 mm versus <1 mm in normal mice). In mice treated with 17beta-estradiol (E2, 0.25-mg subcutaneous pellets), Ang II induced AAA only in 42% of the animals (n=19) with a significant reduction of average diameters of the suprarenal aorta (1.5+/-0.14 mm). E2 also decreased the expressions of intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, E-selectin, monocyte chemotactic protein-1, and macrophage-colony stimulating factor in the aorta. CONCLUSIONS: These data suggest that attenuation of AAA by E2 is associated with inhibition of proinflammatory gene expression.
Martin-McNulty et al. (Tue,) conducted a other in Angiotensin II-induced abdominal aortic aneurysm (n=39). 17beta-estradiol (E2) vs. Angiotensin II alone was evaluated on Incidence of abdominal aortic aneurysm (AAA). Treatment with 17beta-estradiol significantly reduced the incidence of Angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice from 90% to 42%.