Why the study?
Does dihydrotestosterone administration increase AT1a receptor expression and Angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-deficient mice?
Population
Male and female apolipoprotein E-deficient (apoE-/-) mice (including castrated males)
Comparison
Dihydrotestosterone administration during… vs Placebo administration
Design
Preclinical
Follow-up
28 days
Authors
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DHT-driven AAA increase in apoE-deficient mice is hypothesis-generating; leaves open androgen role in human AAA pathogenesis.
Does dihydrotestosterone administration increase AT1a receptor expression and Angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-deficient mice?
Androgen promotes AT1a receptor expression in the abdominal aorta, which is associated with an increased incidence of Angiotensin II-induced abdominal aortic aneurysms in a mouse model.
Henriques et al. (2008) studied this question.
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