Why the study?
Does transient neonatal exposure to testosterone increase susceptibility to AngII-induced abdominal aortic aneurysms in adult female mice?
Does transient neonatal exposure to testosterone increase susceptibility to AngII-induced abdominal aortic aneurysms in adult female mice?
Transient neonatal exposure to testosterone in female mice increases adult susceptibility to abdominal aortic aneurysms by upregulating AT1aR expression, highlighting a developmental mechanism for sexual dimorphism in AAAs.
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Neonatal androgen exposure may program adult AAA susceptibility in females; hypothesis-generating for human sexual dimorphism mechanisms.
Zhang et al. (2012) studied this question.
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