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November 22, 2017Journal of Vascular ResearchOpen Access

Chronic infusion of AngII did not lead to the formation of dissecting AAAs or atherosclerosis in apoE-/- rats, despite causing a rise in BP and microstructural changes in the aortic medial layer.

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Why the study?

Does Angiotensin II infusion cause abdominal aortic aneurysms in Apolipoprotein E-deficient rats?

Population

Apolipoprotein E-deficient rats created with a 16-bp deletion of the apoE gene using transcription…

Design

Preclinical

Follow-up

28 days

Authors

EPEvan H. PhillipsMCMandy S. ChangSGSydney N Gorman

Discussion

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Overview

ApoE-/- rat models may not replicate AngII-induced AAA; challenges mouse-based assumptions and leaves open need for species-validated alternatives.

Structured PICO

Does Angiotensin II infusion cause abdominal aortic aneurysms in Apolipoprotein E-deficient rats?

P
Population
Apolipoprotein E-deficient (apoE-/-) rats created with a 16-bp deletion of the apoE gene using transcription activator-like effector nucleases
I
Intervention
Angiotensin II (AngII, 200 ng/kg/min) infused via miniosmotic pumps for 28 days
O
Outcome
Development of dissecting abdominal aortic aneurysms (AAAs)surrogate

Unlike mice, apoE-/- rats do not develop dissecting abdominal aortic aneurysms or atherosclerosis in response to chronic Angiotensin II infusion, highlighting species-specific differences in cardiovascular disease models.

Cite This Study

Phillips et al. (2017) studied this question.

synapsesocial.com/papers/6a83d57bf4298de60b3c32dahttps://doi.org/10.1159/000484086
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential effects of angiotensin II on atherogenesis at the aortic sinus and descending aorta of apolipoprotein-E-deficient mice2005 · 23 citations
  2. 2Involvement of Vascular Angiotensin II-Forming Enzymes in the Progression of Aortic Abdominal Aneurysms in Angiotensin II- Infused ApoE-Deficient Mice2009 · 35 citations
  3. 3One amino acid change of Angiotensin II diminishes its effects on abdominal aortic aneurysm2019 · 61 citations
  4. 4Effects of Endogenous Angiotensin II on Abdominal Aortic Aneurysms and Atherosclerosis in Angiotensin II-infused Mice2020
  5. 5Associations of ApoAI and ApoB–Containing Lipoproteins With AngII–Induced Abdominal Aortic Aneurysms in Mice2015 · 55 citations