What question did this study set out to answer?

Provide an updated and expanded integrative database to analyze molecular interactions between traditional Chinese medicine ingredients and human target proteins.

October 30, 2023Nucleic Acids ResearchOpen Access

BATMAN-TCM 2.0: an enhanced integrative database for known and predicted interactions between traditional Chinese medicine ingredients and target proteins

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Authors

XKXiangren KongAcademy of Military Medical Sciences CLChao LiuMacau University of Science and Technology ZZZuzhen ZhangAnhui Medical University

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Implication

Bioinformatics database reveals millions of ingredient-target interactions in traditional Chinese medicine, indicating broad utility for modern drug discovery.

Key Points

Provide an updated and expanded integrative database to analyze molecular interactions between traditional Chinese medicine ingredients and human target proteins.
Manually curated known traditional Chinese medicine ingredient-target interactions from literature following established protocols.
Predicted high-confidence interactions between herbal ingredients and target proteins using computational modeling.
Redesigned the web platform to support reciprocal querying of ingredient targets and target-binding ingredients.
Curated 17,068 known ingredient-target interactions, representing a 62.3-fold increase over the initial release.
Predicted approximately 2.3 million high-confidence candidate interactions between traditional medicine ingredients and target proteins.
Implemented simultaneous exploration tools and faster search speeds to support drug discovery and molecular pharmacology.

Cite This Study

Kong et al. (2023) studied this question.

synapsesocial.com/papers/69ff4c2def8139f8ff7753ed https://doi.org/10.1093/nar/gkad926

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Implication

Bioinformatics database reveals millions of ingredient-target interactions in traditional Chinese medicine, indicating broad utility for modern drug discovery.

BATMAN-TCM 2.0: an enhanced integrative database for known and predicted interactions between traditional Chinese medicine ingredients and target proteins

Discussion

Member takes

Implication

Key Points

Cite This Study

BATMAN-TCM 2.0: an enhanced integrative database for known and predicted interactions between traditional Chinese medicine ingredients and target proteins

Discussion

Member takes

Implication

Key Points

Cite This Study

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