What question did this study set out to answer?

To assess the acute and subchronic oral toxicity profiles and metabolic effects of two water-soluble curcuminoid-rich extracts in Wistar rats.

April 5, 2025ACS OmegaOpen Access

Preclinical Safety Assessment and Serum Lipid Profiles of Wister Rats Following Acute and Subchronic Exposure to Water-Soluble Curcuminoid-Rich Extracts

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Authors

AIAcharaporn IssuriyaPrince of Songkla University DCDania CheahaPrince of Songkla University MKMuhammad Mumtaz KhanFederal Urdu University

Discussion

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Implication

Preclinical study reveals safety and improved lipid and glucose levels from water-soluble curcuminoid extracts in rats, highlighting their potential for drug development.

Key Points

To assess the acute and subchronic oral toxicity profiles and metabolic effects of two water-soluble curcuminoid-rich extracts in Wistar rats.
Assessed acute oral toxicity following a single dose of 2000 mg/kg of CRE-Ter or CRE-SD in rats.
Evaluated subchronic toxicity by administering oral doses of 0, 10, 30, and 300 mg/kg/day of CRE-Ter or CRE-SD for 90 days to male and female rats.
Analyzed clinical signs, body weight, food and water consumption, hematological and serum biochemical parameters, and visceral organ histopathology.
Single-dose acute administration of 2000 mg/kg caused no mortality or visible signs of toxicity, establishing the median lethal dose as greater than 2000 mg/kg.
Daily administration up to 300 mg/kg for 90 days produced no adverse toxicological effects on growth, hematology, blood biochemistry, or major organ histology.
Both extracts significantly reduced fasting blood glucose concentrations and improved serum lipid profiles relative to controls.

Cite This Study

Issuriya et al. (2025) studied this question.

synapsesocial.com/papers/69ff6031831589f3542d8874 https://doi.org/10.1021/acsomega.5c00423

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Implication

Preclinical study reveals safety and improved lipid and glucose levels from water-soluble curcuminoid extracts in rats, highlighting their potential for drug development.

Preclinical Safety Assessment and Serum Lipid Profiles of Wister Rats Following Acute and Subchronic Exposure to Water-Soluble Curcuminoid-Rich Extracts

Discussion

Member takes

Implication

Key Points

Cite This Study

Preclinical Safety Assessment and Serum Lipid Profiles of Wister Rats Following Acute and Subchronic Exposure to Water-Soluble Curcuminoid-Rich Extracts

Discussion

Member takes

Implication

Key Points

Cite This Study

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